Abstract
Membrane molecules perform a variety of functions that vital to the survival of organisms. Hence, engineer cell membrane with various biomolecules is a promising means to regulate a variety of bioprocess. Because of high programable nature of nucleic acid, engineering of cell plasma membrane using functional DNA has received considerable attention for temporally regulation of cellular behaviors. In addition to temporal regulation, spatial control of functional DNA modifications on cell membranes is equally important to precisely simulate molecules of interest. Particularly, modification of DNA at the intercellular side of membrane is more challenging due to the difficulties of transport negatively charged DNA across cell membrane barrier. Now, writing in Angew . Chem. Int., Ed., Lin and coworkers introduced a membrane fusion-based transport (LiFT) strategy to enable extra- and intra-cellular modification cell membrane with DNA engineering.
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