Abstract
BackgroundThe current study aimed to discuss the prevalence and surgical outcomes of the asymmetrical Modic changes and identify its correlative factors by multivariate logistic regression analysis.MethodsTwo hundred seventy-eight patients with single-level Modic changes and nerve compression symptoms were reviewed retrospectively from January 2008 to January 2015. 1.5-T MRI was performed to determine the Modic changes. Multivariate logistic regression analysis was used to identify the correlative factors of asymmetrical Modic changes. Surgeries were performed according to the surgical indications. The outcomes were recorded by Japanese Orthopaedic Association (JOA) score, Neck Disability Index (NDI) score, and recovery rate.ResultsAsymmetrical Modic changes were observed in 76 patients (27.34%) with 4 type 1, 69 type 2, and 3 type 3. C5/6 was the most frequently affected segment with 39 patients showing signal changes on MRI. Statistically significant difference was showed in conservative rehabilitation rate between two groups (p = 0.043). Multiple logistic regression analysis identified disc herniation and neurological symptoms as correlative factors of asymmetrical Modic changes, and the adjusted odds ratios (95% CI) were 2.079 (1.348–3.208) and 0.231 (0.143–0.373) respectively. No statistically significant difference was found in JOA scores and NDI scores between the two kinds of Modic changes.ConclusionsC5/6 was the most commonly affected level by Modic changes. Disc herniation and nerve root compression symptom were more closely correlated with asymmetrical Modic changes than conventional Modic changes. Asymmetrical Modic changes indicated poor result in conservative treatment; however, the final operation rate was similar between the two kinds of Modic changes. The outcomes of surgical treatment were satisfactory both in patients with asymmetrical Modic changes and conventional Modic changes.
Highlights
The current study aimed to discuss the prevalence and surgical outcomes of the asymmetrical Modic changes and identify its correlative factors by multivariate logistic regression analysis
Modic changes (MCs) are signal changes of vertebral endplant and subchondral bone marrow on magnetic resonance imaging (MRI), which were first reported by de Roos [1] on lumbar spine
Modic MT [2, 3] classified the signal changes into three types according to signal intensity on T1-weighted and T2-weighted imaging: type 1 was T1 hypointense and T2 hyperintense; type 2 was both T1 and T2 hyperintense; and type 3 was hypointense in both T1 and T2
Summary
The current study aimed to discuss the prevalence and surgical outcomes of the asymmetrical Modic changes and identify its correlative factors by multivariate logistic regression analysis. Modic changes (MCs) are signal changes of vertebral endplant and subchondral bone marrow on magnetic resonance imaging (MRI), which were first reported by de Roos [1] on lumbar spine. Modic MT [2, 3] classified the signal changes into three types according to signal intensity on T1-weighted and T2-weighted imaging: type 1 was T1 hypointense and T2 hyperintense; type 2 was both T1 and T2 hyperintense; and type 3 was hypointense in both T1 and T2. Gao et al Journal of Orthopaedic Surgery and Research (2018) 13:85
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
