Asymmetric transformation of the second kind of racemic naproxen

Abstract

Several chiral derivatives of racemic naproxen were subjected to asymmetric transformations. Notably, asymmetric transformation of the second kind of a mixture of 2b and 3b gave a diastereomeric excess (d.e.) over 90% in favor of 2b. This d.e. was increased to over 99% after recrystallization.