Abstract
AbstractAn efficient Pd/Zn co‐catalyzed method for the asymmetric transfer hydrogenation of trifluoromethylated imines to chiral α‐trifluoromethylated amines using methanol as the hydrogen source has been developed. The reaction showed good substrate scope and the products were obtained in excellent yields (up to 99%) with excellent enantioselectivity. The present methodology was compatible for the synthesis of deuterated chiral α‐trifluoromethylated amines. On using CD3OD as the deuterium source, deuterium incorporation up to 98% was observed without compromising the reaction outcome.
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