Abstract
The catalytic asymmetric transfer hydrogenation (ATH) of acetophenone in isopropanol by Ru(0) nanoparticles (NPs) obtained by the in‐situ reduction of Ru (II) half‐sandwich complexes of chiral 2‐oxazolidinethiones and 2‐thiozolidinethiones was examined and compared with the catalytic activity of Ru(0) NPs formed in‐situ by the reduction of [Ru(p‐cymene)(Cl)2]2 in presence of optically active ligands such as (S)‐4‐isobutylthiazolidine‐2‐thione, (S)‐4‐Isopropyl‐2(−2‐pyridinyl)‐2‐oxazoline, (8S, 9R)‐(−)‐cinchonidine, (S)‐leucinol, (S)‐phenylalaninol, and (S)‐leucine. Three of the best catalytic systems were then examined for ATH of thirteen aromatic ketones with different electronic and steric properties. A maximum of 24% ee was obtained using NPs generated from the Ru (II) half‐sandwich complex with (S)‐4‐isobutylthiazolidine‐2‐thione in the TH of acetophenone. The NPs were characterized by TEM and DLS measurements. Kinetic studies and poisoning experiments confirmed that the reaction is catalyzed by the chiral NPs formed in‐situ. Complete characterization of the complexes, including the X‐ray crystallographic characterization of two complexes, was also carried out.
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