Abstract
Asymmetric total synthesis of five structurally related naturally occurring 14-membered ring resorcylic acid lactones (RALs) have been described in this article through a concise and flexible way. The main highlight of the reported synthetic strategy involves successful application of an atom economical and highly stereoselective Heck reaction. Substrate directed Barbier propargylation, E-selective cross metathesis (CM) reaction, Mitsunobu esterification and late stage electrophilic halogenation reaction are the other key steps used for the total synthesis of the target molecules.
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