Abstract
Abstract The paper studies the asymmetric coupling reaction of (+)-camphor imine (5) from 2-aminomethylpyridine with a variety of oxidative coupling agents. From the coupling product (7), as determined by 1H-NMR, the threo diastereomers are isolated with 80–95% d.e. When FeCl3 or 1.2-dibromoethane is used as oxidative coupling agents, a 93:7 threo: erythro ratio with a d. e. for the threo compound of 95% is obtained.
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