Abstract
AbstractAn alternative route for the synthesis of the C14–C26 building block of the anticancer drug eribulin mesylate is described. The key steps involved in the synthesis are a Julia–Kocienski olefination between aldehyde 4 and sulfone 5 and a tandem Sharpless asymmetric dihydroxylation/SN2 cyclisation reaction on mesyl compound 3.
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