Abstract
AbstractAn efficient [2+2] annulation strategy that isothiourea catalyst homobenzotetramisole (HBTM)‐catalyzed Mannich/lactamization cascade reaction of carboxylic acids with isatin‐derived ketimines has been disclosed. This protocol affords a range of structurally diverse spirooxindole β‐lactams bearing two vicinal stereogenic centers in good to high yields with good to excellent stereoselectivities.magnified image
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