Asymmetric Synthesis of Indoline–Benzodiazepine Scaffold Catalyzed by Chiral Imidodiphosphoric Acids

Abstract

AbstractChiral indoline–benzodiazepines were synthesized via an enantioselective Pictet–Spengler‐type reaction catalyzed by chiral imidodiphosphoric acids. A variety of substitution patterns were achieved at room temperature by using 5 mol % catalysts with high yields (up to 97 %) and enantioselectivities (up to 99 % ee).