Abstract
A convenient asymmetric synthesis of (2 S)-2-amino-3-(2-fluoro-5-hydroxyphenyl) propanoic acid, (2 S)-2-amino-3-(4-fluoro-3-hydroxyphenyl) propanoic acid and (2 S)-2-amino-3-(2-fluoro-4-hydroxyphenyl) propanoic acid is described. Key steps include the synthesis of the benzyl bromides, the alkylation of the glycine enolate derivative (( S)-Boc-BMI) and the hydrolysis of the alkylated Boc-BMI.
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