Asymmetric synthesis of enantiomerically pure spiro[((2 S)-hydroxy)indane-1,4′-piperidine

Abstract

We report herein, efficient and practical synthetic methods for the preparation of enantiomerically pure spiro[((2 S)-hydroxy)indane-1,4′-piperidine] ( S)- 1, a key intermediate for the synthesis of a tachykinin receptor antagonist, using catalytic asymmetric reduction or catalytic asymmetric epoxidation as a key step.