Abstract
AbstractFor the first time, a concise, linear and stereoselective synthesis of both enantiomers of the natural product crispine A has been achieved in six steps with an overall yield of ≥ 20 %, starting from commercially available veratraldehyde. Asymmetric Keck allylation and trifluoroacetic anhydride‐mediated Pummerer cyclization were the key transformations used to construct the tetrahydroisoquinoline core structure.
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