Asymmetric synthesis of car☐yclic C-nucleoside, (−)-9-deazaaristeromycin

Abstract

Enantiomeric synthesis of a carbocyclic C-nucleoside, 9-deazaaristeromycin ( 1) was achieved via the key intermediate 6, which was prepared stereoselectively using Bu 3SnH and subsequent DIBAL-H reduction from the intermediate 4. A new carbocyclic C-nucleoside, (−)-9-deazaaristeromycin was prepared from d-γ-ribonolactone. [Display omitted]