Abstract
The intramolecular Pauson-Khand reaction of (E)-1-alkoxy-1-octen-7-ynes derived from (1S,2R)-2-phenylcyclohexanol is described. 7-Alkoxybicyclo[4.3.0]non-1(9)-en-8-ones are obtained in yields up to 65% and with diastereoselectivities higher than 10:1. The absolute configuration of the major diastereomer obtained has been ascertained and can be rationalized on the basis of the preferential conformation of the precursor.
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