Asymmetric Synthesis of α-Amino Phosphonic Acids Employing Versatile Sulfinimines and Sulfonimines

Abstract

The addition of metallophosphites to activated imino substrates such as sulfonimine 1 and sulfinimines 4 was successfully achieved. High diastereoselectivities and good yields were obtained with sulfinimine acceptors. The nucleophilic addition was applied to the development of a new methodology for the synthesis of enantiomerically homogeneous α-amino phosphonic acids.