Abstract
Abstract In the context of a convergent approach to taxol, the asymmetric synthesis of a fully functionalized C-ring is described. Two asymmetric aldol reactions (Evans) are used to create the C5 and C7 stereocenters and the diastereoselective alkylation of a stereochemically and conformationally biased dioxanone to introduce, with the correct relative and absolute stereochemistry, the quaternary center at C8. Vinyl radical cyclization is used to close the C2,3 bond in good yield. This diastereoselective radical cyclization likely proceeds through a chair-like transition state with the maximum number of substituents equatorially disposed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
