Abstract
King size: Utilization of large-size supramolecular rings in the pre-transition state (pre-TS) of enamine-based Michael reactions for high asymmetric induction is described. Enantiomerically pure, druglike hexahydroxanthenes with three contiguous stereocenters were synthesized through supramolecular catalysis by D-proline and quinine-NH-thiourea followed by reductive etherification from simple precursors under mild conditions (see scheme).
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
