Abstract
Asymmetric reduction of some 3-keto esters (6, 8, and 11) to 3-hydroxy esters (7, 9, and 12) with various chiral reducing agents was investigated. The products (9 and 12) were converted to methyl (2R, 3S)-3-(4-methoxy-phenyl)glycidate (2R, 3S-3), a key intermediate in the practical enantioselective synthesis of dilitazem (1).
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