Asymmetric Pudovik Reaction of Chiral Fluoroalkyl α,β‐Unsaturated Ketimines and Diphenyl Phosphite

Abstract

AbstractThe asymmetric Pudovik reaction of chiral fluoroalkyl α,β‐unsaturated ketimines derivated from (R)‐tert‐butanesulfinamide and diphenyl phosphite was achieved in the presence of Rb2CO3 at room temperature. A series of fluoroalkylated α‐amino phosphonates were prepared in good yields with high diastereoselectivities.