Asymmetric Organocatalytic Electrophilic Phosphination

Abstract

Meeting the challenge: The first asymmetric catalytic C*P bond formation employing electrophilic phosphorus compounds has been developed using a catalytic amount of a dimeric cinchona alkaloid, and a subsequent one-pot process to deliver high stereoselectivities and good yields of α-quaternary α-phosphino β-amino acids (see scheme). 31P NMR experiments suggest a novel reaction mechanism wherein a cinchona alkaloid nucleophilically activates the phosphorus electrophile. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.