Abstract
Additions of nucleophiles to electron-deficient double bonds, e.g. the classical Michael addition or the CuI-mediated 1,4-addition of Grignard reagents to α,β-unsaturated carbonyl compounds (see previous chapters of this volume), constitute some of the very valuable items in the toolbox of the synthetic organic chemist. No wonder that they have found widespread application in organic synthesis. While early interest in these reactions was based particularly on their reliable chemo- and regio-selectivity, in recent years much progress has been made in the development of highly diastereo- and even enantio-selective methods, allowing the control of absolute stereochemistry.1–4
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