Abstract

Asymmetric addition of 2-cyanoproprionates to methyl vinyl ketone in the presence of 1 mol% of chiral Rh(I) catalysts containing a novel chiral bisphosphine ligand ((R)-7,7'-bis(diphenylphosphinomethyl)-2,2'-dimethoxy-1,1'-binaphthyl) gave optically active Michael adducts in good yields with enantiomeric excesses up to 73% ee.

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