Abstract
Abstract A series of novel chiral 5-(substituted aryl)-1,3,4-thiadiazole derivatives was synthesized in an enantioselective three-component Mannich reaction using cinchona alkaloid squaramide catalyst with excellent enantioselectivities (up to >99% enantiomeric excess (ee)). The bioassay results showed that these derivatives possessed good to excellent activities against tobacco mosaic virus (TMV).
Highlights
The design and synthesis of novel compounds that have value as agricultural therapeutic agents is one of the fundamental objectives of organic chemistry
A series of novel chiral 5-(substituted aryl)-1,3,4thiadiazole derivatives was synthesized in an enantioselective three-component Mannich reaction using cinchona alkaloid squaramide catalyst with excellent enantioselectivities (up to >99% enantiomeric excess)
The bioassay results showed that these derivatives possessed good to excellent activities against tobacco mosaic virus (TMV)
Summary
The design and synthesis of novel compounds that have value as agricultural therapeutic agents is one of the fundamental objectives of organic chemistry.
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