Abstract
AbstractStannous chloride efficiently catalyzes condensations between α‐isocyanoacetamides (1) and a variety of aldehydes to afford the corresponding 5‐amino‐2‐(1‐hydroxyalkyl)oxazoles (3) in good to excellent yields. The [Sn‐(R)‐Ph‐PyBox](OTf)2‐catalyzed reaction between 1a and 2‐(benzyloxy)acetaldehyde (2g) shows an isoinversion effect, with the maximum enantiomeric excess of oxazole 3g (80 %) being obtained at –40 °C. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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