Abstract
The structural biology of the exporter class of ABC transporters has witnessed rapid advances owing to a deluge of cryoEM structures ranging from single snapshots of substrate- or ATP-bound structures to the complement of structures populated under ATP turnover conditions. However, long standing mechanistic gaps remain including the sequence of events linking ATP hydrolysis in the nucleotide binding domains (NBDs) to isomerization of the transmembrane domains (TMD) and how substrate binding stimulates ATP hydrolysis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
