Abstract
Several chirally-modified nucleophilic carbenes afford useful levels of asymmetric induction during [1+4] cycloaddition with vinyl isocyanate reaction partners. Carbenes derived from the 1,2-aminoalcohols (1R,2S)-ephedrine and (1R,2S)-methylaminoindanol proved to be the most effective for delivering high levels of asymmetric induction.
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