Abstract

Abstract Asymmetric induction during the aminolysis of 5(4H)-oxazolones from N-benzoyl amino acids was investigated using a series of amino acid esters as amine nucleophiles. The reaction of the oxazolone from N-benzoyl-Dl-t-Meucine with methyl l-prolinate was found to produce the diastereomeric Dl isomer, almost specifically, under appropriate conditions.

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