Asymmetric hydrolyses of 1,2- and 1,3-diacetoxycyclohexanes with the cultured suspension cells ofMarchantia polymorpha

Abstract

Very high enantioselectivities were observed in the hydrolysis of racemic 1,2- and 1,3-diacetoxycyclohexanes and their derivatives by cultured cells of Marchantia polymorpha in suspension. Asymmetry was also induced in the hydrolyses of meso-1,2- and 1,3-diacetates to the corresponding monoacetates. These findings indicate that these cultured cells hydrolyze the acetoxyl groups enantioselectively at the stereogenic center of R-configuration. Chirality 9:250–253, 1997. © 1997 Wiley-Liss, Inc.