Abstract
The asymmetric hydrogenation of aromatic ketones catalysed by L-proline derivative- and PPh3-modified 1.0%Ru/γ-Al2O3 was studied. The effects of different stabilisers, P/Ru ratio, modifiers, modifier concentration, solvents, base additives and base concentration on the asymmetric hydrogenation of aromatic ketones were investigated. The results showed that L-proline derivatives had good modification effects on the 1.0%Ru/γAl2O3/2tpp catalyst. Under optimum conditions, the hydrogenation enantioselectivity of acetophenone was 70%. The enantioselectivity of the hydrogenation product of propiophenone could reach 81%.
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