Abstract
A highly enantioselective hetero-Diels-Alder reaction of Danishefsky's diene with α-ketoesters and isatins has been realized by using a chiral N,N'-dioxide/Mg(II) complex. In the presence of only 0.1-0.5 mol % catalyst, a series of substrates were transformed into the corresponding tetrasubstituted 2,3-dihydropyran-4-ones in up to 99 % yield and more than 99 % ee in two hours.
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