Asymmetric grignard cross-coupling reaction between (E)-β-bromostyrene and 1-phenylethylmagnesium chloride

Abstract

Trans-2,3-bis-(diphenylphosphinomethyl)-norbornene-(5), trans-2,3-bis-(diphenylphosphinomethyl)-7-oxanorbornane, and (−)-/2((S)-1-dimethylaminoethyl)-phenyl/-diphenylphosphine have been used as ligands for the nickel and palladium catalyzed asymmetric Grignard cross-coupling reaction giving the coupling product ( E)-1,3-diphenyl-1-butene. Chemical yields from 60 to 95% and optical yields up to 40% were obtained, depending on the types of ligand coordinated.