Abstract
Abstract2‐Allyl‐3‐furfural could generate dearomative trienamine species in the presence of a chiral secondary amine, and underwent an asymmetric remote ϵ‐regioselective Michael addition reaction with isatin‐derived α,α‐dicyanoalkenes. Meanwhile, the more challenging dearomative tetraenamine intermediate from 5‐allyl‐2‐furfural could be similarly utilized in very remote η‐regioselective Michael additions. In general, good yields with moderate to high enantioselectivity were obtained by employing a concerted activation strategy of bifunctional secondary amine/thiourea catalysts.
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