Asymmetric direct aldol reactions catalyzed by chiral amine macrocycle–metal(ii) complexes under solvent-free conditions

Abstract

Solvent-free asymmetric aldol reactions between cyclohexanone and 4-nitrobenzaldehyde using chiral amine macrocycle–metal(II) complexes as catalysts in a ball mill afforded the anti-aldol product as the major isomer with up to 93% ee.