Asymmetric dimethylarginine serum levels are associated with patient characteristics after renal transplant

Abstract

Objectives: To investigate the changes in asymmetric plasma dimethylarginine (ADMA) levels after six months of renal transplant and their potential associations with patient characteristics. Subjects and methods: From March 2018 to April 2020, a prospective enrolled 75 recipients 6 months after renal transplant at Military Hospital 103. Results: The average ADMA concentration at 6th month of the transplant was 0.57 µmol/L, a statistically significant decrease from the time before transplant (0.62 µmol/L) with p < 0.05, but still higher than the healthy controls (0.17 µmol/L), p < 0.001. At 6th month following the transplant, 32.0% of patients had an increase and 68.0% had a decrease in ADMA concentration. After transplant, increased ADMA concentration was found to be positively correlated with the atherogenesis index (r = 0,468) and negatively correlated with the glomerular filtration rate (r = -0.261, p < 0.05). Conclusion: Six months after renal transplant, plasma ADMA decreased significantly but remained higher than in healthy people. Following the transplant, both the atherogenesis index and the glomerular filtration rate were significantly associated with an increase in ADMA levels. * Keywords: Asymmetric Dimethylarginine;