Abstract
Objective Research of statins influence on flow induced vasodilatation reveals controversial results. Design and methods We analyze whether asymmetric dimethylarginine (ADMA) levels influence the effect of 80 mg/day simvastatin on flow-mediated vasodilation (%FMD). A total of 200 hypercholesterolemic patients were enrolled. Biochemistry parameters were examined by routine methods. Determination of %FMD was performed with software MedicaSoft. Patients were assigned into two groups according to the ADMA level. Results Simvastatin, 80 mg/day for 1 month, resulted in changes in routine lipid profile and apolipoproteins, but there was not reduction of ADMA and homocysteine. In the group with ADMA < 1.03 μmol/L a significant increase of %FMD was observed, whereas no such was found in the group with ADMA ≥ 1.03 μmol/L. %FMD-change correlated significant with baseline level of Apo-В and АDMA. Conclusion Asymmetric dimethylarginine level was found to determine the effect of high-dose simvastatin on %FMD.
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