Abstract
An efficient method for the enantio- and diastereoselective construction of multisubstituted tetrahydrofurans via asymmetric decarboxylative cycloaddition of vinylethylene carbonates with β-nitroolefins under a cooperative catalysis of palladium complex and squaramide is developed. By using a palladium complex generated in situ from Pd2(dba)3·CHCl3 and phosphoramidite L1 and chiral squaramide OC4 as cooperative catalysts under mild conditions, the process provided multisubstituted tetrahydrofurans bearing a quaternary stereocenter in good to high yields with acceptably high enantio- and diastereoselectivities.
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