Abstract
AbstractA new asymmetric Brønsted acid‐catalyzed cascade reaction involving a 1,4‐addition, enantioselective protonation and 1,2‐addition has been developed. This organocatalytic cascade not only provides for the first time 3‐ and 2,3‐substituted tetrahydroquinolines and octahydroacridines in good yields with high dia‐ and enantioselectivities under mild reaction conditions but additionally represents the first example of a chiral Brønsted acid‐catalyzed protonation reaction in an organocatalytic domino reaction. Furthermore, the new Brønsted acid‐catalyzed hydride‐proton‐hydride transfer cascade can be applied to prepare new molecular scaffolds with up to three new stereocenters in an efficient one‐pot reaction sequence.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.