Asymmetric conjugate addition of diethylzinc to chalcone catalyzed by nickel complexes containing derivatives of (1 R,2 S,3 R)-3-mercaptocamphan-2-ol

Abstract

In the presence of Ni complexes and chiral ligand 1b, the asymmetric conjugate addition of diethylzinc to chalcone in acetonitrile at −30°C proceeded in 86% e.e. The factors influencing the enantioselectivity of the reaction were studied.