Abstract

The exchange of the metal ion from Zr(IV) to Fe(III) leads to a switch in the enantioselectivity of binary acid-catalyzed conjugate hydride reductions. In the presence of Hantzsch ester, γ-indolyl β,γ-unsaturated α-keto esters could be reduced to the desired (S)- or (R)-products, respectively, with good to excellent enantioselectivity (up to 98% ee).

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