Abstract
The enantioselective addition of chiral benzylic amines to dimethyl maleate and fumarate gives optically active aspartic acid in satisfactory yields. The re-face favorably meets the stereochemical requirements of the chiral R-amines than does the si-face. The stereoselectivity in the present reaction is little dependent on solvent polarity but is significantly enhanced by low temperature. The direct determination by gas-liquid chromatography of the diastereomeric addition products provides more precise values of optical yield and is preferred to the polarimetry of the end product after many steps of transformation with probable fractionations.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
