Abstract
Asymmetric allylic substitution reactions work with a variety of carbon, oxygen, nitrogen, and sulfur nucleophiles (see Review below). However, the use of highly reactive organo-metallic reagents such as organolithiums or Grignard reagents still remains a challenge. The authors previously showed that, under certain conditions, lithiated 2-methylpyridine could participate in allylic alkylations with good yields and reactivity (B. M. Trost, D. A. Thaisrivongs J. Am. Chem. Soc. 2008, 130, 14092). In the present communication, a much wider range of nitrogen-containing heterocycles are shown to undergo similar reactivity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
