Abstract
An asymmetric allylation reaction at the benzylic position of furfurals that are easily accessed from 5-HMF, which is a biomass derivative, has been established by palladium and amine cooperative catalysis. The high levels of enantioselectivity of up to 97% enantiometric excess (ee) were enabled by the synergistic stereochemical control of a chiral TADDOL-based phosphoramidite ligand and a chiral diphenylprolinol silyl ether. The product could be feasibly transformed to chiral aryl-substituted spiroacetal via a four-step reaction sequence.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
