Asymmetric alkylation reaction of α-fluorotetralone under phase-transfer catalyzed conditions

Abstract

The catalytic asymmetric alkylation reaction of α-fluorotetralones promoted by a chiral quaternary ammonium salt derived from cinchonine under phase-transfer catalyzed conditions was described. The reaction proceeded smoothly to give the desired products with up to 91 % ee. This methodology provides a practical protocol for the preparation of optically active fluoro compounds on a large scale.