Abstract
Chiral boron enolates based on the 1,3-oxazolidin-2-one auxiliary react with achiral 1-phenyl-sulfanylcycloalkanecarbaldehydes in anti- and syn-selective aldol processes to give the corresponding aldol products with moderate to excellent levels of diastereo- and enantio-control. Stereospecific cyclisation via an asymmetric episulfonium (thiiranium) ion leads to optically pure spirocyclic compounds in high chemical yields.
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