Asymmetric addition of alkynes to imines in water catalyzed with a recyclable Cu(I)–bis(oxazoline) and stearic acid system

Juntao Liu,Bao Liu,Xian Jia,Xingshu Li,Albert S.C Chan

doi:10.1016/j.tetasy.2007.02.005

Asymmetric addition of alkynes to imines in water catalyzed with a recyclable Cu(I)–bis(oxazoline) and stearic acid system

Juntao Liu, Bao Liu + Show 3 more

https://doi.org/10.1016/j.tetasy.2007.02.005

Copy DOI

Journal: Tetrahedron: Asymmetry	Publication Date: Feb 1, 2007
Citations: 35

Affiliation: Sun Yat-sen University, Shenyang Pharmaceutical University, Hong Kong Polytechnic University

#Imines In Water #Zinc Salt + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

Stearic acid and its zinc salt were used as additives in the enantioselective alkyne addition to imines catalyzed by copper(I)–bis(oxazoline) (box) in water. The reactions took place smoothly with good yields and high enantioselectivities (up to 97% ee). Good enantioselectivities were maintained in a catalyst recycle study.

Full Text