Abstract
AbstractPolystyrene (PS)‐supported diphenylprolinol silyl ethers have been developed as highly active catalysts for the enantioselective α‐amination of aldehydes. Understanding the mechanism of catalyst deactivation has led to the development of reaction conditions notably extending catalyst life in repeated recycling (10 cycles; accumulated TON of 480) and has allowed the implementation of a continuous flow α‐amination process (6 min residence time, 8 h operation).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have