Abstract
The article provides a detailed analysis of modern publications focused on a studies an astrovirus gastroenteritis. Based on our own examination of 3470 children with acute intestinal infections aged from 1 month to 1 8 years old, who were treated at the Children's Research and Clinical Center for Infectious Diseases, FMBA of Russia, St. Petersburg, from May 201 7 to July 2018 a detailed description of the characteristic epidemiological, clinical and laboratory features of the disease is given. It was shown, that astroviruses remain a significant causative agent of acute intestinal infections in children, accounting for 1.36% of all cases of disease. Among the combined forms of astrovirus infection, associations with rotaviruses, noroviruses and campylobacter spp. are most common. It was established, that the disease is more often observed in boys aged 1 to 3 years. Clinical course of astrovirus infection in children is characterized by an acute or gradual onset with repeated vomiting, moderate intoxication and symptoms of gastroenteritis. Due to the lack of pathognomonic clinical and laboratory features of the course of viral gastroenteritis, diagnosis is necessary using laboratory methods including molecular genetic research methods.
Highlights
The article provides a detailed analysis of modern publications focused on a studies an astrovirus gastroenteritis
Based on our own examination of 3470 children with acute intestinal infections aged from 1 month to 18 years old, who were treated at the Children's Research and Clinical Center for Infectious Diseases, FMBA of Russia, St
Conflict of interest: The authors confirmed the absence conflict of interest, financial support, which should be reported
Summary
В статье проводится подробный анализ современных публикаций, посвящённых результатам исследования астровирусной кишечной инфекции. На основании собственного обследования 3470 детей с ОКИ в возрасте от 1 месяца до 18 лет, проходивших лечение в клинике ФГБУ ДНКЦИБ ФМБА России в период с мая 2017 по июль 2018 гг., дается подробное описание характерных эпидемиологических, клинических и лабораторных особенностей заболевания. Что астровирусы являются одними из значимых возбудителей ОКИ у детей, составляя 1,36% всех случаев заболеваний. Установлено, что заболевание чаще отмечается у мальчиков в возрасте от 1 до 3 лет, в клинической картине астровирусной инфекции у детей преобладает острое или постепенное начало с повторной рвоты, проявлениями умеренной интоксикации и симптомами гастроэнтерита. В связи с отсутствием патогномоничных клинико-лабораторных особенностей течения астровирусного гастроэнтерита, необходима диагностика с помощью лабораторных, в том числе молекулярно-генетических методов исследования.
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