Abstract
The epidemiologic features of the morphologic entity of hypertrophic astrocytes unaccompanied by amphophilic globules in infant cerebral white matter (HA · GL ) have been studied in a selected autopsy population of 191 infants. During the 3 years of this study the pattern of changes in the annual frequency of HA · GL in the base population most closely resembled the patterns of congenital heart disease (CHD) and cardiac catheterization. When the 33 infants with HA · GL and the 80 infants without any white matter abnormality were grouped by postnatal or total (gestational plus postnatal) age, CHD was the risk factor most closely associated with HA · GL . It is speculated that infants with CHD may be at heightened risk of HA · GL because of oxygen toxicity, prolonged hypoxia, unrecognized hypoglycemia, undernutrition, heightened risk of bacterial infection, or persistent viral infection.
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