Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders

Angelo Lu ,Jae‐Won Hyun ,Marius Ringelstein ,Yang Mao-Draayer ,Srilakshmi M Sharma ,Rahele Kafieh ,Adriana Roca-Fernández ,Alexander U Brandt ,Ari J Green ,Allyson Reid ,Terry J Smith ,Svenja Specovius ,Álvaro Cobo‐Calvo ,Hadas Stiebel‐Kalish ,Eugene May ,Caryl Tongco ,Lekha Pandit ,Mariana Andrade Fontenelle ,Maria Isabel Leite ,Ibis Soto De Castillo ,Seyedamirhosein Motamedi ,Charlotte Bereuter ,Axel Petzold ,Zoe Rimler ,Nasrin Asgari ,Marco Aurélio Lana-Peixoto ,Marta Radaelli ,Su-Kyung Jung ,Lawrence J Cook ,Fereshteh Ashtari ,Uygur Tanriverdi ,Anu Jacob ,Orhan Aktaş ,Philipp Albrecht ,Joachim Havla ,Michael R Yeaman ,Hanna Zimmermann ,Jacqueline Palace ,Saif Huda ,Ayse Altıntaş ,Romain Marignier ,Denis Bernardi Bichuetti ,Rengin Yıldırım ,Kerstin Soelberg ,Elena H Martínez-Lapiscina ,Jérôme De Sèze ,Letizia Leocani ,Ivan Maynart Tavares ,Thomas Senger ,Ho Jin Kim ,Friedemann Paul ,Claudia Chien ,Marco Pisa ,Alireza Dehghani ,Anitha D’cunha ,Mohsen Pourazizi ,Sasitorn Siritho ,Frederike Cosima Oertel

doi:10.1136/jnnp-2021-327412

Abstract

BackgroundPatients with anti-aquaporin-4 antibody seropositive (AQP4-IgG+) neuromyelitis optica spectrum disorders (NMOSDs) frequently suffer from optic neuritis (ON) leading to severe retinal neuroaxonal damage. Further, the relationship of this retinal damage...

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